Activators
The modules abstraction allowed us to label regulator-module edges in the
graph to indicate whether there is significant evidence that regulators may
be functioning as activators. We searched for activator relationships by
examining regulators with expression profiles that are positively correlated
with the expression profiles of genes in the corresponding modules.
Positive correlation indicates that higher levels of regulator expression
correlate with higher levels of expression of genes in the module and
suggests that the transcription factor positively regulates the expression of
genes in the module. We determined the statistical significance of the
activator relationships by computing correlation coefficients between all
factors and all modules and taking the 5% positive tail of the distribution
of correlation coefficients. Supplemetary Table 2
presents the eleven activators
determined using the method described above.
In this page we provide the full list of modules
that have been observed to be regulated by an activator.
The results are described at the following table.
Modules are described by their module number.
This number corresponds to the module number in our
modules file.
In addition, for two of the factors on the list, we present
figures that demonstrate the relationships between their expression values
and the expression values of the modules they regulate (across all
of the 500 expression experiments).
Activator Examples
